Publicaciones

Sola-Leyva A, Pérez-Prieto I, Di Nisio V, Panagiotis-Deligiannis S, Blanco-Rodríguez L, Acharya G, Saare M, Papaikonomou K, Damdimopoulou P, Salumets A, Altmäe S. Assessing the ovarian microbiome: lack of a distinguishable microbial signature beyond contamination. Reprod Biomed Online. 2025;104988. doi: 10.1016/j.rbmo.2025.104988.
Molina NM, Canha-Gouveia A, Leonés-Baños I, Sola-Leyva A, Vargas E, Ruíz-Durán S, Tenorio CM, Clavero-Gilabert A, Mändar R, Altmäe S. The complementary seminovaginal microbiome in health and disease. Reprod Biomed Online. 2025 May;50(5):104707. doi: 10.1016/j.rbmo.2024.104707
Tenorio CM, Molina NM, Castilla JA, Rodríguez-Guirado S, Méndez R, Fernández-Godino R, Altmäe S, Díaz C. Refining the seminal biomarker detection: metabolome profiles before and after the liquefaction procedure. Reprod Biomed Online. 2025;104856. doi: 10.1016/j.rbmo.2025.104856.
Toporcerová S, Badovská Z, Kriváková E, Mikulová V, Mareková M, Altmäe S, Rabajdová M. Embryo secretome in predicting embryo quality and in vitro fertilization treatment outcome. Reprod Biomed Online. 2025;104825. doi: 10.1016/j.rbmo.2025.104825
Plaza-Florido A, Anguita-Ruiz A, Esteban FJ, Aguilera CM, Labayen I, Reitzner SM, Sundberg CJ, Radom-Aizik S, Ortega FB, Altmäe S. Integrated analysis of methylome and transcriptome responses to exercise training in children with overweight/obesity. Physiol Genomics. 2025 Feb 1;57(2):91-102. doi: 10.1152/physiolgenomics.00059.2024. PMID: 39751206.
Sola-Leyva A, Romero B, Canha-Gouveia A, Pérez-Prieto I, Molina NM, Vargas E, Mozas-Moreno J, Chamorro C, Saare M, Salumets A, Altmäe S. Uterus didelphys: the first case report on molecular profiling of endometrial tissue from both uterine cavities. Reprod Biol Endocrinol. 2025 Jan 4;23(1):1. doi: 10.1186/s12958-024-01330-7. PMID: 39755646.

Pérez-Prieto I, Plaza-Florido A, Ubago-Guisado E, Ortega FB, Altmäe S. Physical activity, sedentary behavior and microbiome: A systematic review and meta-analysis. J Sci Med Sport. 2024 Nov;27(11):793-804. doi: 10.1016/j.jsams.2024.07.003.
Pérez-Prieto I, Vargas E, Salas-Espejo E, Lüll K, Canha-Gouveia A, Pérez LA, Fontes J, Salumets A, Andreson R, Aasmets O; Estonian Biobank research team; Whiteson K, Org E, Altmäe S. Gut microbiome in endometriosis: a cohort study on 1000 individuals. BMC Med. 2024 Jul 18;22(1):294. doi: 10.1186/s12916-024-03503-y. PMID: 39020289.
Ruiz-González D, Cavero-Redondo I, Hernández-Martínez A, Baena-Raya A, Martínez-Forte S, Altmäe S, Fernández-Alonso AM, Soriano-Maldonado A. Comparative efficacy of exercise, diet and/or pharmacological interventions on BMI, ovulation, and hormonal profile in reproductive-aged women with overweight or obesity: a systematic review and network meta-analysis. Hum Reprod Update. 2024 Jul 1;30(4):472-487. doi: 10.1093/humupd/dmae008. PMID: 38627233.
Pérez-Prieto I, Rodríguez-Santisteban A, Altmäe S. Beyond the reproductive tract: gut microbiome and its influence on gynecological health. Curr Opin Clin Nutr Metab Care. 2024 Jun 1;36(3):134-147. doi: 10.1097/01.gco.0001016536.06312.72. Epub 2024 Apr 8. PMID: 38656809.
Bui BN, Kukushkina V, Meltsov A, Olsen C, van Hoogenhuijze N, Altmäe S, Mol F, Teklenburg G, de Bruin JP, Besselink D, Stevens Brentjens L, Obukhova D, Zamani Esteki M, van Golde R, Romano A, Laisk T, Steba G, Mackens S, Salumets A, Broekmans F. The endometrial transcriptome of infertile women with and without implantation failure. Acta Obstet Gynecol Scand. 2024 Jul;103(7):1348-1365. doi: 10.1111/aogs.14822. Epub 2024 Mar 22. PMID: 38520066.
Muñoz E, Bronet F, Lledo B, Palacios-Verdú G, Martinez-Rocca L, Altmäe S, Pla J; representing the Special Interest Group in Reproductive Genetics of the Spanish Society of Fertility. To transfer or not to transfer: the dilemma of mosaic embryos - a narrative review. Reprod Biomed Online. 2024 Mar;48(3):103664. doi: 10.1016/j.rbmo.2023.103664. Epub 2023 Nov 2. PMID: 38408811.
Van den Berg JS, Molina NM, Altmäe S, Arends B, Steba GS. A systematic review identifying seminal plasma biomarkers and their predictive ability on IVF and ICSI outcomes. Reprod Biomed Online. 2024 Feb;48(2):103622. doi: 10.1016/j.rbmo.2023.103622. Epub 2023 Oct 18. PMID: 38128376.
Bui BN, Ardisasmita AI, Kuijk E, Altmäe S, Steba G, Mackens S, Fuchs S, Broekmans F, Nieuwenhuis E. An unbiased approach of molecular characterization of the endometrium: toward defining endometrial-based infertility. Hum Reprod. 2024 Feb 1;39(2):275-281. doi: 10.1093/humrep/dead257. PMID: 38099857.
Pérez-Prieto I, Migueles JH, Molina NM, Sola-Leyva A, Salas-Espejo E, Arffman RK, Nurkkala M, Niemelä M, Lüll K, Org E, Franks S, Tapanainen JS, Salumets A, Piltonen TT, Ortega FB, Altmäe S. Association of Accelerometer-Determined Physical Activity and Sedentary Behavior With the Gut Microbiome in Middle-Aged Women: A Compositional Data Approach. Scand J Med Sci Sports. 2024 Jul;34(7):e14689. doi: 10.1111/sms.14689. PMID: 38946228.
Altmäe S, Plaza-Florido A, Esteban FJ, Anguita-Ruiz A, Krjutškov K, Katayama S, Einarsdottir E, Kere J, Radom-Aizik S, Ortega FB. Effects of exercise on whole-blood transcriptome profile in children with overweight/obesity. Am J Hum Biol. 2024 Feb;36(2):e23983. doi: 10.1002/ajhb.23983. Epub 2023 Sep 16. PMID: 37715654.

Salas-Espejo E, Terrón-Camero LC, Ruiz JL, Molina NM, Andrés-León E. Exploring the Microbiome in Human Reproductive Tract: High-Throughput Methods for the Taxonomic Characterization of Microorganisms. Semin Reprod Med. 2023 Sep;41(5):125-143. doi: 10.1055/s-0044-1779025. Epub 2024 Feb 6. PMID: 38320576.
Canha-Gouveia A, Pérez-Prieto I, Rodríguez CM, Escamez T, Leonés-Baños I, Salas-Espejo E, Prieto-Sánchez MT, Sánchez-Ferrer ML, Coy P, Altmäe S. The female upper reproductive tract harbors endogenous microbial profiles. Front Endocrinol (Lausanne). 2023

Sola-Leyva A, Pérez-Prieto I, Molina NM, Vargas E, Ruiz-Durán S, Leonés-Baños I, Canha-Gouveia A, Altmäe S. Microbial composition across body sites in polycystic ovary syndrome: a systematic review and meta-analysis. Reprod Biomed Online. 2023

Molina NM, Jurado-Fasoli L, Sola-Leyva A, Sevilla-Lorente R, Canha-Gouveia A, Ruiz-Durán S, Fontes J, Aguilera CM, Altmäe S. Endometrial whole metabolome profile at the receptive phase: influence of Mediterranean Diet and infertility. Front Endocrinol (Lausanne). 2023

Altmäe S, Sola-Leyva A, Salumets A. Artificial intelligence in scientific writing: a friend or a foe? Reprod Biomed Online. 2023

Plaza-Florido A, Rodriguez-Ayllon M, Altmäe S, Ortega FB, Esteban-Cornejo I. Cardiorespiratory fitness and targeted proteomics involved in brain and cardiovascular health in children with overweight/obesity. Eur J Sport Sci. 2023

Rodriguez-Ayllon M, Plaza-Florido A, Mendez-Gutierrez A, Altmäe S, Solis-Urra P, Aguilera CM, Catena A, Ortega FB, Esteban-Cornejo I. The effects of a 20-week exercise program on blood-circulating biomarkers related to brain health in overweight or obese children: The ActiveBrains project. J Sport Health Sci. 2023
Stewart-Morgan KR*, Requena CE*, Flury V, Du Q, Heckhausen Z, Hajkova P, Groth A. Quantifying propagation of DNA methylation and hydroxymethylation with iDEMS. Nat Cell Biol. 2023 Jan;25(1):183-193. doi: 10.1038/s41556-022-01048-x. Epub 2023 Jan 12. PMID: 36635504. *These authors contributed equally.

Koel M, Krjutškov K, Saare M, Samuel K, Lubenets D, Katayama S, Einarsdottir E, Vargas E, Sola-Leyva A, Lalitkumar PG, Gemzell-Danielsson K, Blesa D, Simon C, Lanner F, Kere J, Salumets A, Altmäe S. Human endometrial cell-type-specific RNA sequencing provides new insights into the embryo-endometrium interplay. Hum Reprod Open. 2022

Oses M, Medrano M, Margareto Sanchez J, Portillo MP, Aguilera CM, Altmäe S, Labayen I. Peripheral blood mononuclear cells-expressed miRNA profiles derived from children with metabolic-associated fatty liver disease and insulin resistance. Pediatr Obes. 2022

Plaza-Florido A, Pérez-Prieto I, Molina-Garcia P, Radom-Aizik S, Ortega FB, Altmäe S. Corrigendum: Transcriptional and epigenetic response to sedentary behavior and physical activity in children and adolescents: A systematic review. Front Pediatr. 2022

Plaza-Florido A, Pérez-Prieto I, Molina-Garcia P, Radom-Aizik S, Ortega FB, Altmäe S.Transcriptional and Epigenetic Response to Sedentary Behavior and Physical Activity in Children and Adolescents: A Systematic Review. Front Pediatr. 2022

Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, Kiesel L, King K, Kvaskoff M, Nap A, Petersen K, Saridogan E, Tomassetti C, van Hanegem N, Vulliemoz N, Vermeulen N; ESHRE Endometriosis Guideline Group.ESHRE guideline: endometriosis. Hum Reprod Open. 2022

Vargas E, García-Moreno E, Aghajanova L, Salumets A, Horcajadas JA, Esteban FJ, Altmäe S. The mid-secretory endometrial transcriptomic landscape in endometriosis: a meta-analysis. Hum Reprod Open. 2022

Altmäe S, Kullisaar T. GenitouGenitourinary microbial screening for all infertile men? Nat Rev Urol. 2022

Molina NM, Plaza-Díaz J, Vilchez-Vargas R, Sola-Leyva A, Vargas E, Mendoza-Tesarik R, Galán-Lázaro M, Mendoza-Ladrón de Guevara N, Tesarik J, Altmäe S. Assessing the testicular sperm microbiome: a low-biomass site with abundant contamination. Reprod Biomed Online. 2021
Plaza-Florido A, Altmäe S, Esteban FJ, Löf M, Radom-Aizik S, Ortega FB. Cardiorespiratory fitness in children with overweight/obesity: Insights into the molecular mechanisms. Scand J Med Sci Sports. 2021
Altmäe S, Rienzi L. Endometrial microbiome: new hope, or hype?. Reprod Biomed Online. 2021
Läänelaid S, Ortega FB, Kunovac Kallak T, Joelsson L, Ruiz JR, Hreinsson J, Wånggren K, Stavreus-Evers A, Kalda R, Salumets A, Altmäe S. Physical and Sedentary Activities in Association with Reproductive Outcomes among Couples Seeking Infertility Treatment: A Prospective Cohort Study. Int J Environ Res Public Health. 2021
Sola-Leyva A, Andrés-León E, Molina NM, Terron-Camero LC, Plaza-Díaz J, Sáez-Lara MJ, Gonzalvo MC, Sánchez R, Ruíz S, Martínez L, Altmäe S. Mapping the entire functionally active endometrial microbiota. Human Reproduction. 2021
Molina NM, Sola-Leyva A, Haahr T, Aghajanova L, Laudanski P, Castilla JA, Altmäe S. Analysing endometrial microbiome: methodological considerations and recommendations for good practice. Human Reproduction. 2021
Huang TC, Wang YF, Vazquez-Ferrer E, Theofel I, Requena CE, Hanna CW, Kelsey G, Hajkova P. Sex-specific chromatin remodelling safeguards transcription in germ cells. Nature. 2021 Dec;600(7890):737-742. doi: 10.1038/s41586-021-04208-5. Epub 2021 Dec 8. PMID: 34880491.
Zhu Q, Sang F, Withey S, Tang W, Dietmann S, Klisch D, Ramos-Ibeas P, Zhang H, Requena CE, Hajkova P, Loose M, Surani MA, Alberio R. Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage. Cell Rep. 2021 Feb 9;34(6):108735. doi: 10.1016/j.celrep.2021.108735. PMID: 33567277.

Altmäe S, Molina NM, Sola-Leyva A. Omission of non-poly(A) viral transcripts from the tissue level atlas of the healthy human virile. BMC Biology. 2020
Lüll K, Arffman RK, Sola-Leyva A et al. The gut microbiome in Polycystic Ovary Syndrome (PCOS) and its Association with Metabolic Traits. The Journal of Clinical Endocrinology & Metabolism. 2020
Henriksson P, Lentini A, Altmäe S. et al. DNA methylation in infants with low and high body fatness. BMC genomics. 2020 doi:10.1186/s12864-020-07169-7
Haahr T, Jensen J S, Altmäe S. et al. Low biomass microbiota in the upper genital tract of reproductive age women: fact or fiction?. Annals of Clinical Microbiology and Antimicrobials. 2020 doi:10.1186/s12941-020-00385-9
Sõritsa D., Mäestu E, Nuut M, et al. Maternal physical activity and sedentary behaviour before and during in vitro fertilization treatment: a longitudinal study exploring the associations with controlled ovarian stimulation and pregnancy outcomes. Journal of Assisted Reproduction and Genetics. 2020 dot:10.1007/s10815-020-01864-w
Molina Morales N, Sola Leyva A, Sáez Lara M J. et al. New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future? Biomolecules. 2020 doi:10.3390/biom10040593.
Vargas E, Aghajanova L, Gemzell-Danielsson K, et al. Cross-disorder analysis of endometriosis and its comorbid diseases reveals shared genes and molecular pathways and proposes putative biomarkers of endometriosis. Reproductive Biomedicine Online. 2020 doi:10.1016/j.rbmo.2019.11.003
Altmäe S, Franasiak JM, Mändar R. The seminal microbiome in health and disease. Nature Review Urology. 2020 doi:10.1038/s41585-019-0250-y
Martínez-Arribas B, Requena CE, Pérez-Moreno G, Ruíz-Pérez LM, Vidal AE, González-Pacanowska D. DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools. Cell Mol Life Sci. 2020 Apr;77(8):1645-1660. doi: 10.1007/s00018-019-03250-x. Epub 2019 Aug 3. PMID: 31377845.

Dukatz M*, Requena CE*, Emperle M, Hajkova P, Sarkies P, Jeltsch A. Mechanistic Insights into Cytosine-N3 Methylation by DNA Methyltransferase DNMT3A. J Mol Biol. 2019 Aug 9;431(17):3139-3145. doi: 10.1016/j.jmb.2019.06.015. Epub 2019 Jun 21. PMID: 31229457. *These authors contributed equally.

Suhorutshenko M, Kukushkina V, Velthut-Meikas A, et al. Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity. Human Reproduction. 2018 doi:10.1093/humrep/dey301 2018
Rekker K, Altmäe S, Suhorutshenko M, et al. A Two-Cohort RNA-seq Study Reveals Changes in Endometrial and Blood miRNome in Fertile and Infertile Women. Genes (Basel). 2018 doi:10.3390/genes9120574
Wyck S, Herrera C, Requena CE, Bittner L, Hajkova P, Bollwein H, Santoro R. Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development. Epigenetics Chromatin. 2018 Oct 17;11(1):60. doi: 10.1186/s13072-018-0224-y. PMID: 30333056.
Hill PWS, Leitch HG*, Requena CE*, Sun Z*, Amouroux R, Roman-Trufero M, Borkowska M, Terragni J, Vaisvila R, Linnett S, Bagci H, Dharmalingham G, Haberle V, Lenhard B, Zheng Y, Pradhan S, Hajkova P. Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte. Nature. 2018 Mar 15;555(7696):392-396. doi: 10.1038/nature25964. Epub 2018 Mar 7. PMID: 29513657. *These authors contributed equally.
Rošić S*, Amouroux R*, Requena CE*, Gomes A, Emperle M, Beltran T, Rane JK, Linnett S, Selkirk ME, Schiffer PH, Bancroft AJ, Grencis RK, Jeltsch A, Hajkova P, Sarkies P. Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity. Nat Genet. 2018 Mar;50(3):452-459. doi: 10.1038/s41588-018-0061-8. Epub 2018 Feb 19. PMID: 29459678. *These authors contributed equally.

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